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Article

Nucleosomal DNA Fragments in Autoimmune Diseases

1 Sept 2006

Abstract excerpt

The inadequate response of immune cells to circulating apoptotic products, such as nucleosomal DNA fragments, is assumed to be a potent stimulus for the production of autoantibodies during the pathogenesis and progression of systemic lupus erythematosus (SLE). Here, we analyzed the levels of circulating nucleosomes, caspases, and C-reactive protein in sera of 244 individuals with various autoimmune diseases (155...

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PMID: 17108227
DOI: 10.1196/annals.1368.043

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