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Nephritogenic Potential of Anti-DNA Antibodies against Necrotic Nucleosomes

30 Mar 2009

Abstract excerpt

Systemic lupus erythematosus is an inflammatory autoimmune syndrome of unknown cause. Kidney disease is a central and serious complication in this syndrome. Deposition of chromatin-containing immune complexes within glomerular membranes is considered a key event in the pathogenesis of lupus nephritis. One set of autoantibodies that participate in these complexes is directed against components of chromatin,...

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PMID: 19329762
DOI: 10.1681/asn.2008010112

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