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Article

The role of nucleosomes in lupus

1 Sept 2000

Abstract excerpt

Nucleosomes play a central role in the antinuclear antibody response in lupus. Lupus anti-dsDNA and antihistone antibodies directed toward nucleosomes belong together with nucleosome-specific antibodies, to a broad antinucleosome antibody family. Besides anti-dsDNA, nucleosome-specific antibodies have a major role in the pathophysiology of systemic lupus erythematosus (SLE) and emphasize the role of...

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PMID: 10990171
DOI: 10.1097/00002281-200009000-00003

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