Multiple mutations in human cancers.

doi:10.1016/0027-5107(95)00117-4

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Article

Multiple mutations in human cancers.

Mutation research - 19 Feb 1996

Loeb L A, Christians F C

Abstract excerpt

Increasing evidence indicates that most human cancers contain multiple mutations. The exact number of mutations, their origin, and types remain to be determined. An over-riding question is whether the multiple mutations that accumulate in cancers is rate-limiting for the carcinogenic process. In...

Topics

Carcinoma, Hepatocellular
Cell Division
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
Disease Progression
Humans
Liver Neoplasms
Lung Neoplasms
Male
Microsatellite Repeats
Mutation
Neoplasms
Phenotype
Prostatic Neoplasms

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