Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

L2dtl is essential for cell survival and nuclear division in early mouse embryonic development.

The Journal of biological chemistry - 12 Jan 2007

Liu Chao-Lien, Yu I-Shing, Pan Hung-Wei, Lin Shu-Wha, Hsu Hey-Chi

Abstract excerpt

l(2)dtl (lethal (2) denticleless), is an embryonic lethal homozygous mutation initially identified in Drosophila melanogaster that produces embryos that lack ventral denticle belts. In addition to nucleotide sequence, bioinformatic analysis has revealed a conservation of critical functional motifs among the human L2DTL, mouse L2dtl, and Drosophila l(2)dtl proteins. The function of the L2DTL protein in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Blastomeres

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Embryonic Stem Cells

Share to Genes, Lethal

Share to HeLa Cells

Share to RNA, Small Interfering

Share to Ubiquitin-Protein Ligases

Source

Identifiers

PMID: 17107960
DOI: 10.1074/jbc.M606535200

Genes

PTTG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L2dtl is essential for cell survival and nuclear division in early mouse embryonic development.PMID 17107960Read ↗

Characterization of null and hypomorphic alleles of the Drosophila l(2)dtl/cdt2 gene: Larval lethality and male fertility.Semantic proximity Read ↗

DIS3L2 is essential for neural crest survival by modulating Akt signalingSemantic proximity Read ↗

Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases.Semantic proximity Read ↗

DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint.Semantic proximity Read ↗

The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila.Semantic proximity Read ↗

RNA polymerase II subunit D is essential for zebrafish development.Semantic proximity Read ↗

Two dynamin-2 genes are required for normal zebrafish development.Semantic proximity Read ↗

Mammalian Llgl2 is necessary for proper branching morphogenesis during placental development.Semantic proximity Read ↗

dELL is an essential RNA polymerase II elongation factor with a general role in development.Semantic proximity Read ↗

Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo.Semantic proximity Read ↗

Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction.Semantic proximity Read ↗

Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.