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Article

Beta-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast.

Cell cycle (Georgetown, Tex.) - 1 Nov 2006

Menacho-Márquez Mauricio, Murguía José R

Abstract excerpt

Beta-lapachone is an anticancer agent that selectively induces cell death in several human cancer cells. The mechanism of beta-lapachone cytotoxicity is not yet fully understood. Here we report that beta-lapachone treatment delayed cell cycle progression at the G(1)/S transition, incremented phosphorylation of the Rad53p checkpoint kinase and decreased cell survival in the budding yeast Saccharomyces cerevisiae....

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Identifiers

PMID: 17106258
DOI: 10.4161/cc.5.21.3394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Beta-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast.PMID 17106258Read ↗

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