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Article

TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18.

Molecular and cellular biology - 1 Jun 2009

Huang Yi-Fu, Chang Margaret Dah-Tsyr, Shieh Sheau-Yann

Abstract excerpt

Upon prolonged arrest in mitosis, cells undergo adaptation and exit mitosis without cell division. These tetraploid cells are either eliminated by apoptosis or arrested in the subsequent G(1) phase in a spindle checkpoint- and p53-dependent manner. p53 has long been known to be activated by spindle poisons, such as nocodazole and Taxol, although the underlying mechanism remains elusive. Here we present evidence...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Processing, Post-Translational

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Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins c-mdm2

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Source

Open in PubMed Open full text

Identifiers

PMID: 19332559
DOI: 10.1128/MCB.01837-08
PMCID: PMC2682006

Genes

TTK
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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