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Article

Promotion of homologous recombination and genomic stability by RAD51AP1 via RAD51 recombinase enhancement.

Molecular cell - 9 Nov 2007

Wiese Claudia, Dray Eloïse, Groesser Torsten, San Filippo Joseph, Shi Idina, Collins David W, Tsai Miaw-Sheue, Williams Gareth J, Rydberg Bjorn, Sung Patrick, Schild David

Abstract excerpt

Homologous recombination (HR) repairs chromosome damage and is indispensable for tumor suppression in humans. RAD51 mediates the DNA strand-pairing step in HR. RAD51 associated protein 1 (RAD51AP1) is a RAD51-interacting protein whose function has remained elusive. Knockdown of RAD51AP1 in human cells by RNA interference engenders sensitivity to different types of genotoxic stress, and RAD51AP1 is epistatic to...

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Identifiers

PMID: 17996711
DOI: 10.1016/j.molcel.2007.08.027
PMCID: PMC2169287

Genes

RAD51
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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