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Article

Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome.

Cellular and molecular life sciences : CMLS - 1 Jul 2014

Bharti Sanjay Kumar, Khan Irfan, Banerjee Taraswi, Sommers Joshua A, Wu Yuliang, Brosh Robert M

Abstract excerpt

In 2010, a new recessive cohesinopathy disorder, designated Warsaw breakage syndrome (WABS), was described. The individual with WABS displayed microcephaly, pre- and postnatal growth retardation, and abnormal skin pigmentation. Cytogenetic analysis revealed mitomycin C (MMC)-induced chromosomal breakage; however, an additional sister chromatid cohesion defect was also observed. WABS is genetically linked to...

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Identifiers

PMID: 24487782
DOI: 10.1007/s00018-014-1569-4
PMCID: PMC4537069

Genes

DDX11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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