Article
Mcl1p is a polymerase alpha replication accessory factor important for S-phase DNA damage survival.
Eukaryotic cell - 1 Jan 2005
Williams Dewight R, McIntosh J R
Abstract excerpt
Mcl1p is an essential fission yeast chromatin-binding protein that belongs to a family of highly conserved eukaryotic proteins important for sister chromatid cohesion. The essential function is believed to result from its role as a Pol1p (polymerase alpha) accessory protein, a conclusion based primarily on analogy to Ctf4p's interaction with Pol1p. In this study, we show that Mcl1p also binds to Pol1p with high...
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