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Article

Model cell culture system for defining the molecular and biochemical events mediating terminal differentiation of human melanoma cells.

Journal of cellular physiology - 1 Feb 2009

Staudt Michelle R, Depass Anthony L, Sarkar Devanand, Fisher Paul B

Abstract excerpt

Cancer cells are commonly less differentiated than their normal progenitors; a phenotype that correlates with loss of specialized functions and an increased capability to self-renew. Melanoma is an ideal model to analyze cancer progression and differentiation since a well-characterized process of step-wise tumor progression has been defined. Our lab previously described a combinatorial in vitro treatment protocol...

Topics

Cell Culture Techniques
Cell Cycle
Cell Differentiation
Cell Line, Tumor
Cell Proliferation
Cluster Analysis
Diterpenes
Enzyme Activators
Gene Expression Profiling
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Interferon-beta

Isoenzymes

Melanoma

Oligonucleotide Array Sequence Analysis

Phenotype

Protein Kinase C

Protein Kinase Inhibitors

Source

Identifiers

PMID: 18844238
DOI: 10.1002/jcp.21602

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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