Article
Alteration of melanoma melanogenesis by phenotypic modifiers.
The Journal of dermatology - 1 Nov 1992
Takahashi H, Horikoshi T, Wakamatsu K, Ito S, Parsons P G
Abstract excerpt
Human melanoma cells (MM96E) were incubated with a phenotypic modifier (L-ethionine) to compare its effects on phenotypic expression with those induced by sodium butyrate and dimethyl sulfoxide. In contrast to the latter agents, L-ethionine (8mM) failed to arrest the cell cycle at the G1 phase or to inhibit colony formation ability after 48 hr incubation. Tyrosinase activity changed in parallel with...
Topics
- Alkaline Phosphatase
- Butyrates
- Butyric Acid
- Cell Division
- Dimethyl Sulfoxide
- Ethionine
- Humans
- Melanins
- Melanoma, Experimental
- Monophenol Monooxygenase
- Phenotype
- Skin Neoplasms