Article
Inhibition of induced melanogenesis in Cloudman melanoma cells by four phenotypic modifiers.
Experimental cell research - 1 Dec 1990
Orlow S J, Chakraborty A K, Boissy R E, Pawelek J M
Abstract excerpt
Retinoic acid, hexamethylene bisacetamide, sodium butyrate, and dimethylsulfoxide, four compounds which modulate phenotypic expression in a variety of neoplastic cell lines, all inhibited the induction of tyrosinase activity and melanogenesis by the combination of melanocyte-stimulating hormone and isobutylmethyxanthine in Cloudman S91 melanoma cells. Results were the same in assays of whole cells or in extracts...
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