Article
The lactose repressor system: paradigms for regulation, allosteric behavior and protein folding.
Cellular and molecular life sciences : CMLS - 1 Jan 2007
Wilson C J, Zhan H, Swint-Kruse L, Matthews K S
Abstract excerpt
In 1961, Jacob and Monod proposed the operon model for gene regulation based on metabolism of lactose in Escherichia coli. This proposal was followed by an explication of allosteric behavior by Monod and colleagues. The operon model rationally depicted how genetic mechanisms can control metabolic events in response to environmental stimuli via coordinated transcription of a set of genes with related function...
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