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Article

Integrity of the Mod(mdg4)-67.2 BTB domain is critical to insulator function in Drosophila melanogaster.

Molecular and cellular biology - 1 Feb 2007

Golovnin Anton, Mazur Alexander, Kopantseva Marina, Kurshakova Maria, Gulak Pavel V, Gilmore Brian, Whitfield William G F, Geyer Pamela, Pirrotta Vincenzo, Georgiev Pavel

Abstract excerpt

The Drosophila gypsy insulator contains binding sites for the Suppressor of Hairy-wing [Su(Hw)] protein. Enhancer and silencer blocking require Su(Hw) recruitment of Mod(mdg4)-67.2, a BTB/POZ domain protein that interacts with Su(Hw) through a carboxyl-terminal acidic domain. Here we conducted mutational analyses of the Mod(mdg4)-67.2 BTB domain. We demonstrate that this domain is essential for insulator...

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Identifiers

PMID: 17101769
DOI: 10.1128/MCB.00795-06
PMCID: PMC1800699

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Integrity of the Mod(mdg4)-67.2 BTB domain is critical to insulator function in Drosophila melanogaster.PMID 17101769Read ↗

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