Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.

FEBS letters - 27 Nov 2006

Yissachar Nissan, Salem Hagit, Tennenbaum Tamar, Motro Benny

Abstract excerpt

Members of the NIMA-related kinases (NRK) family are recently emerging as central regulators of various aspects of the cell cycle. However, the cellular roles of the mammalian NRK, Nek7, remain obscure. We show here that the endogenous Nek7 protein is enriched at the centrosome in a microtubule-independent manner. Overexpression of wt or kinase-defective Nek7 resulted in cells of rounder appearance, and higher...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Centrosome
Share to Giant Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Mitosis

Share to NIMA-Related Kinases

Share to Protein Serine-Threonine Kinases

Share to Spindle Apparatus

Source

Identifiers

PMID: 17101132
DOI: 10.1016/j.febslet.2006.10.069

Genes

NRK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nek7 kinase is enriched at the centrosome, and is required for proper spindle assembly and mitotic progression.PMID 17101132Read ↗

The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.Semantic proximity Read ↗

Cell cycle regulation by the NEK family of protein kinasesSemantic proximity Read ↗

An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.Semantic proximity Read ↗

NEK7 is required for G1 progression and procentriole formationSemantic proximity Read ↗

Targeting NEK2 as a promising therapeutic approach for cancer treatmentSemantic proximity Read ↗

The NIMA-related kinase family and cancerSemantic proximity Read ↗

Role of NEK2A in Human Cancer and Its Therapeutic PotentialsSemantic proximity Read ↗

Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.Semantic proximity Read ↗

Less is More: Nek2A Unclusters Extra Centrosomes and Induces Cell Death in Cancer Cells via KIF2C InteractionSemantic proximity Read ↗

On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage ResponseSemantic proximity Read ↗

Nip2/centrobin may be a substrate of Nek2 that is required for proper spindle assembly during mitosis in early mouse embryos.Semantic proximity Read ↗

Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.