Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.

The Journal of biological chemistry - 30 Jul 2004

Noguchi Kohji, Fukazawa Hidesuke, Murakami Yuko, Uehara Yoshimasa

Abstract excerpt

We previously reported that Nek11, a member of the NIMA (never-in-mitosis A) family of kinases, is activated in G(1)/S-arrested cells. We provide herein several lines of evidence for a novel interaction between Nek11 and Nek2A. Both Nek11 and Nek2A, but not Nek2B, were detected at nucleoli, and the Nek2A-specific C-terminal end (amino acids 399-445) was responsible for nucleolar localization. Endogenous Nek11...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Cell Nucleolus
Share to G1 Phase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luminescent Proteins

Share to NIMA-Related Kinases

Share to Octoxynol

Share to Precipitin Tests

Share to S Phase

Source

Identifiers

PMID: 15161910
DOI: 10.1074/jbc.M404104200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleolar Nek11 is a novel target of Nek2A in G1/S-arrested cells.PMID 15161910Read ↗

Targeting NEK2 as a promising therapeutic approach for cancer treatmentSemantic proximity Read ↗

An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9.Semantic proximity Read ↗

Cell cycle regulation by the NEK family of protein kinasesSemantic proximity Read ↗

Alternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinase.Semantic proximity Read ↗

The NIMA-related kinase family and cancerSemantic proximity Read ↗

A Comprehensive Analysis Revealing NEK2 as an oncogene in the Tumor MicroenvironmentSemantic proximity Read ↗

Role of NEK2A in Human Cancer and Its Therapeutic PotentialsSemantic proximity Read ↗

The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis.Semantic proximity Read ↗

Extracellular signal-regulated kinase 2 (ERK2) mediates phosphorylation and inactivation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA) at G2/M.Semantic proximity Read ↗

Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors.Semantic proximity Read ↗

NIMA related kinase 2 promotes gastric cancer cell proliferationviaERK/MAPK signalingSemantic proximity Read ↗

Upregulation of NEK2 is associated with drug resistance in ovarian cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.