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Article

Allelotyping analyses of synchronous primary and metastasis CIN colon cancers identified different subtypes.

International journal of cancer - 1 Feb 2007

Weber Jean-Christophe, Meyer Nicolas, Pencreach Erwan, Schneider Anne, Guérin Eric, Neuville Agnès, Stemmer Christine, Brigand Cécile, Bachellier Philippe, Rohr Serge, Kedinger Michèle, Meyer Christian, Guenot Dominique, Oudet Pierre, Jaeck Daniel, Gaub Marie-Pierre

Abstract excerpt

In colorectal cancer, the molecular alterations that lead to metastasis are not clearly established, probably because of their high genetic complexity. To identify combinations of genetic changes involved in tumor progression and metastasis, we focused on chromosome instable (CIN) colon cancers. We compared by allelotyping of 33 microsatellites, the genomic alterations of 38 primary colon tumors with the...

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PMID: 17096353
DOI: 10.1002/ijc.22343

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