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Article

Genetic evolution in colon cancer KM12 cells and metastatic derivates

15 Apr 2004

Abstract excerpt

So far, CRC cell lines have contributed to descriptions of 2 patterns of genetic instability, affecting either microsatellite sequences or chromosome number and structure. Often, these patterns are mutually exclusive; while near-diploid karyotypes usually appear with MSI and chromosomal stability, near-triploid or tetraploid cells display a high degree of CIN and are stable at the microsatellite level. In the...

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PMID: 15170669
DOI: 10.1002/ijc.20195

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