Article
Use of multivariate analysis to suggest a new molecular classification of colorectal cancer.
The Journal of pathology - 1 Feb 2013
Domingo Enric, Ramamoorthy Rajarajan, Oukrif Dahmane, Rosmarin Daniel, Presz Michal, Wang Haitao, Pulker Hannah, Lockstone Helen, Hveem Tarjei, Cranston Treena, Danielsen Havard, Novelli Marco, Davidson Brian, Xu Zheng-Zhou, Molloy Peter, Johnstone Elaine, Holmes Christopher, Midgley Rachel, Kerr David, Sieber Oliver, Tomlinson Ian
Abstract excerpt
Molecular classification of colorectal cancer (CRC) is currently based on microsatellite instability (MSI), KRAS or BRAF mutation and, occasionally, chromosomal instability (CIN). Whilst useful, these categories may not fully represent the underlying molecular subgroups. We screened 906 stage II/III CRCs from the VICTOR clinical trial for somatic mutations. Multivariate analyses (logistic regression, clustering,...
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