Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modification of the Tet-On regulatory system prevents the conditional-live HIV-1 variant from losing doxycycline-control.

Retrovirology - 9 Nov 2006

Zhou Xue, Vink Monique, Berkhout Ben, Das Atze T

Abstract excerpt

BACKGROUND: We have previously constructed a doxycycline (dox)-dependent HIV-1 variant by incorporating the Tet-On gene regulatory system into the viral genome. Replication of this HIV-rtTA virus is driven by the dox-inducible transactivator protein rtTA, and can be switched on and off at will. We proposed this conditional-live virus as a novel vaccine approach against HIV-1. Upon vaccination, replication of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Doxycycline
Share to Gene Expression Regulation, Viral
Share to Gene Products, tat

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Engineering

Share to Mutagenesis, Site-Directed

Share to Operator Regions, Genetic

Share to tat Gene Products, Human Immunodeficiency Virus

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 17094796
DOI: 10.1186/1742-4690-3-82
PMCID: PMC1637113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modification of the Tet-On regulatory system prevents the conditional-live HIV-1 variant from losing doxycycline-control.PMID 17094796Read ↗

The genetic stability of a conditional live HIV-1 variant can be improved by mutations in the Tet-On regulatory system that restrain evolution.Semantic proximity Read ↗

Optimization of the Tet-On system for regulated gene expression through viral evolution.Semantic proximity Read ↗

Viral evolution as a tool to improve the tetracycline-regulated gene expression system.Semantic proximity Read ↗

<i>In vitro</i> evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studiesSemantic proximity Read ↗

Improving the safety of a conditional-live human immunodeficiency virus type 1 vaccine by controlling both gene expression and cell entry.Semantic proximity Read ↗

Constitutively dead, conditionally live HIV-1 genomes. Ex vivo implications for a live virus vaccine.Semantic proximity Read ↗

Controlling Multicycle Replication of Live-Attenuated HIV-1 Using an Unnatural Genetic SwitchSemantic proximity Read ↗

Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes.Semantic proximity Read ↗

Conditional expression of vaccinia virus genes in mammalian cell lines expressing the tetracycline repressor.Semantic proximity Read ↗

Transcriptional Feedback Disruption Yields Escape-Resistant AntiviralsSemantic proximity Read ↗

Evolutionary analysis of human immunodeficiency virus type 1 therapies based on conditionally replicating vectors.Semantic proximity Read ↗

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.