Article
<i>In vitro</i> evolution of a highly replicating, doxycycline-dependent HIV for applications in vaccine studies
15 May 2001
Abstract excerpt
A major concern associated with the use of vaccines based on live-attenuated viruses is the possible and well documented reversion to pathogenic phenotypes. In the case of HIV, genomic deletions or mutations introduced to attenuate viral pathogenicity can be repaired by selection of compensating mutations. These events lead to increased virus replication rates and, eventually, disease progression. Because...
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