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Article

Controlling Multicycle Replication of Live-Attenuated HIV-1 Using an Unnatural Genetic Switch

21 Jan 2017

Abstract excerpt

A safe and effective human immunodeficiency virus type 1 (HIV-1) vaccine is urgently needed, but remains elusive. While HIV-1 live-attenuated vaccine can provide potent protection as demonstrated in rhesus macaque-simian immunodeficiency virus model, the potential pathogenic consequences associated with the uncontrolled virus replication preclude such vaccine from clinical applications. We investigated a novel...

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PMID: 28106981
DOI: 10.1021/acssynbio.6b00373

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