Transcriptional Feedback Disruption Yields Escape-Resistant Antivirals

Abstract excerpt

From microbes to cancers, drug-resistant ‘escape’ variants cause significant morbidity and mortality 1–7 . Here we present proof-of-concept that disruption of viral auto-regulatory (feedback) circuits strongly inhibits viral replication and confers an extremely high barrier to the evolution of resistance. Using DNA duplexes, we develop single-molecule ‘feedback-circuit disruptors’ that interfere with transcriptio...

Topics

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• Adaptation, Physiological
• Animal Disease Management and Epidemiology
• Animal Virus Infections Studies
• Cytomegalovirus and herpesvirus research
• Herpesvirus Infections and Treatments
• Mutation
• Viral Infections and Immunology Research
• Viruses

Identifiers and source

Literature Corpus work

74fdb348-1d53-5d4f-96e8-44404f700273

DOI

10.1101/464495