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Article

Evolutionary analysis of human immunodeficiency virus type 1 therapies based on conditionally replicating vectors.

PLoS computational biology - 1 Jan 2012

Ke Ruian, Lloyd-Smith James O

Abstract excerpt

Efforts to reduce the viral load of human immunodeficiency virus type 1 (HIV-1) during long-term treatment are challenged by the evolution of anti-viral resistance mutants. Recent studies have shown that gene therapy approaches based on conditionally replicating vectors (CRVs) could have many advantages over anti-viral drugs and other approaches to therapy, potentially including the ability to circumvent the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23133349
DOI: 10.1371/journal.pcbi.1002744
PMCID: PMC3486895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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