Article
Constitutively dead, conditionally live HIV-1 genomes. Ex vivo implications for a live virus vaccine.
The Journal of biological chemistry - 24 Aug 2001
Smith S M, Khoroshev M, Marx P A, Orenstein J, Jeang K T
Abstract excerpt
An effective vaccine against AIDS is unlikely to be available for many years. As we approach two decades since the first identification of human immunodeficiency virus, type 1 (HIV-1), currently, only one subunit vaccine candidate has reached phase 3 of clinical trials. The subunit approach has been criticized for its inability to elicit effectively cytotoxic T-lymphocyte (CTL) response, which is felt by many to...
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