Mutagenic consequences of the incorporation of 6-thioguanine into DNA.

doi:10.1016/s0006-2952(97)00200-1

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Article

Mutagenic consequences of the incorporation of 6-thioguanine into DNA.

Biochemical pharmacology - 1 Aug 1997

Uribe-Luna S, Quintana-Hau J D, Maldonado-Rodriguez R, Espinosa-Lara M, Beattie K L, Farquhar D, Nelson J A

Abstract excerpt

6-Thioguanine (S6G) has been used in the treatment of acute leukemias because of its cytotoxic effect on proliferating leukemic cells. The cytotoxicity of S6G is thought to derive from its incorporation into DNA in place of guanine. The deoxyribonucleoside triphosphate of S6G, SdGTP, is a good su...

Topics

Bacterial Proteins
DNA
DNA Replication
Deoxyguanine Nucleotides
Escherichia coli
Escherichia coli Proteins
Lac Repressors
Mutagens
Mutation
Repressor Proteins
Thioguanine
Thionucleotides

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