Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutagenic consequences of the incorporation of 6-thioguanine into DNA.

Biochemical pharmacology - 1 Aug 1997

Uribe-Luna S, Quintana-Hau J D, Maldonado-Rodriguez R, Espinosa-Lara M, Beattie K L, Farquhar D, Nelson J A

Abstract excerpt

6-Thioguanine (S6G) has been used in the treatment of acute leukemias because of its cytotoxic effect on proliferating leukemic cells. The cytotoxicity of S6G is thought to derive from its incorporation into DNA in place of guanine. The deoxyribonucleoside triphosphate of S6G, SdGTP, is a good substrate for bacterial and human DNA polymerases (Ling et al., Mol Pharmacol 40: 508-514, 1991). Since SdGTP was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to DNA
Share to DNA Replication

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Escherichia coli Proteins

Share to Mutagens

Share to Mutation

Share to Repressor Proteins

Source

Identifiers

PMID: 9278101
DOI: 10.1016/s0006-2952(97)00200-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutagenic consequences of the incorporation of 6-thioguanine into DNA.PMID 9278101Read ↗

Mutagenic and cytotoxic properties of 6-thioguanine, S6-methylthioguanine, and guanine-S6-sulfonic acid.Semantic proximity Read ↗

Relative mutagenic potencies of several nucleoside analogs, alone or in drug pairs, at the HPRT and TK loci of human TK6 lymphoblastoid cells.Semantic proximity Read ↗

Possible carcinogenic effect of 6-mercaptopurine on bone marrow stem cellsSemantic proximity Read ↗

Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.Semantic proximity Read ↗

Induction of micronuclei by four cytostatic compounds in human hematopoietic stem cells and human lymphoblastoid TK6 cells.Semantic proximity Read ↗

Effects of 6-thioguanine and S6-methylthioguanine on transcription in vitro and in human cells.Semantic proximity Read ↗

The involvement of WT1 in the regulation of GADD45a in response to genotoxic stress.Semantic proximity Read ↗

Genetic consequences of tolerance to methylation DNA damage in mammalian cells.Semantic proximity Read ↗

Induction of A:T to G:C transition mutations by 5-(2-chloroethyl)-2'-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue, in the bone marrow of Muta Mouse.Semantic proximity Read ↗

Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus.Semantic proximity Read ↗

Induction of T --> G and T --> A transversions by 5-formyluracil in mammalian cells.Semantic proximity Read ↗

Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.