Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease.

doi:10.1016/0092-8674(91)90645-f

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Article

Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease.

Cell - 25 Jan 1991

Vassar R, Coulombe P A, Degenstein L, Albers K, Fuchs E

Abstract excerpt

To explore the relationship between keratin gene mutations and genetic disease, we made transgenic mice expressing a mutant keratin in the basal layer of their stratified squamous epithelia. These mice exhibited abnormalities in epidermal architecture and often died prematurely. Blistering occurr...

Topics

Animals
Epithelium
Humans
Intermediate Filament Proteins
Keratins
Mice
Mice, Transgenic
Mutation
Phenotype
Skin
Skin Diseases

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