Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

doi:10.1002/j.1460-2075.1993.tb05738.x

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Article

Targeting expression of keratinocyte growth factor to keratinocytes elicits striking changes in epithelial differentiation in transgenic mice.

The EMBO journal - 1 Mar 1993

Guo L, Yu Q C, Fuchs E

Abstract excerpt

Keratinocyte growth factor (KGF) is a member of the fibroblast growth factor (FGF) family. Synthesized by cells of the dermal component of skin, KGF's potent mitogenic activity is on the epidermal component, which harbors the receptors for this factor. To explore the possible role of KGF in mesenchymal-epithelial interactions in skin, we used a human keratin 14 promoter to target expression of human KGF cDNA to...

Topics

Animals
Animals, Newborn
Base Sequence
Cell Differentiation
Cell Division
Cell Transformation, Neoplastic
DNA, Single-Stranded
Epithelial Cells
Epithelium
Fibroblast Growth Factor 10
Fibroblast Growth Factor 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibroblast Growth Factors

Growth Substances

Hair

Humans

Keratinocytes

Keratins

Mesoderm

Source

Open in PubMed Open full text

Identifiers

PMID: 7681397
DOI: 10.1002/j.1460-2075.1993.tb05738.x
PMCID: PMC413298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7681397-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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