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Article

Transcription affects formation and processing of intermediates in oligonucleotide-mediated gene alteration.

Nucleic acids research - 15 May 2003

Igoucheva Olga, Alexeev Vitali, Pryce Melissa, Yoon Kyonggeun

Abstract excerpt

The role of transcription in oligonucleotide (ODN)-directed gene modification has been investigated in mammalian cells. The importance of transcription is demonstrated using mammalian cell lines with varying degrees of transcription of the mutant LacZ reporter gene, residing in both episome and chromosome. Gene correction occurs more efficiently when the target gene is actively transcribed and antisense ODN is...

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Identifiers

PMID: 12736316
DOI: 10.1093/nar/gkg360
PMCID: PMC156042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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