Article
On the mutagenicity of homologous recombination and double-strand break repair in bacteriophage.
DNA repair - 2 Jan 2011
Shcherbakov Victor P, Plugina Lidiya, Shcherbakova Tamara, Sizova Svetlana, Kudryashova Elena
Abstract excerpt
The double-strand break (DSB) repair via homologous recombination is generally construed as a high-fidelity process. However, some molecular genetic observations show that the recombination and the recombinational DSB repair may be mutagenic and even highly mutagenic. Here we developed an effective and precise method for studying the fidelity of DSB repair in vivo by combining DSBs produced site-specifically by...
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