Article
RraA. a protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli.
Cell - 5 Sept 2003
Lee Kangseok, Zhan Xiaoming, Gao Junjun, Qiu Ji, Feng Yanan, Meganathan R, Cohen Stanley N, Georgiou George
Abstract excerpt
Ribonuclease E (RNase E) has a key role in mRNA degradation and the processing of catalytic and structural RNAs in E. coli. We report the discovery of an evolutionarily conserved 17.4 kDa protein, here named RraA (regulator of ribonuclease activity A) that binds to RNase E and inhibits RNase E endonucleolytic cleavages without altering cleavage site specificity or interacting detectably with substrate RNAs....
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