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Article

Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner

1 Sept 2012

Abstract excerpt

Denial of the appropriate cell-matrix interaction in epithelial cells induces apoptosis and is called 'anoikis'. Cancer cells are resistant to anoikis and it is believed that the resistance to anoikis helps promote tumor malignancy especially metastasis. We and others have demonstrated that the expression of tight junction protein claudin-1 is highly upregulated in colorectal cancer (CRC) and helps promote tumor...

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PMID: 22941059
DOI: 10.1093/carcin/bgs275

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