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Article

Association of TET1 expression with colorectal cancer progression

16 Nov 2016

Abstract excerpt

OBJECTIVE: The ten-eleven translocation (TET) proteins, as methylcytosine dioxygenases, catalyze 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). The altered expression of TET1 disrupts the balance between DNA methylation and demethylation. This alteration has been reported to be associated with carcinogenesis in various malignancies. The aim of the present study was to investigate changes in...

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PMID: 27846738
DOI: 10.1080/00365521.2016.1253767

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