Article
Alpha-synuclein haplotypes implicated in risk of Parkinson's disease.
Neurology - 13 Jan 2004
Tan E K, Chai A, Teo Y Y, Zhao Y, Tan C, Shen H, Chandran V R, Teoh M L, Yih Y, Pavanni R, Wong M C, Puvan K, Lo Y L, Yap E
Abstract excerpt
The authors examined four- and six-loci haplotype constructs (from five single nucleotide polymorphisms and three microsatellite regions) of the alpha-synuclein gene in patients with Parkinson's disease (PD) and controls in an ethnic Chinese population. Logistic regression analysis demonstrated an association of NACP-Rep1 (p = 0.002) and L478 (p < 0.0001) with risk of PD after correction for the effects of age,...
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