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Article

ADAM12-S Stimulates Bone Growth in Transgenic Mice by Modulating Chondrocyte Proliferation and Maturation

26 Jul 2006

Abstract excerpt

UNLABELLED: ADAM12-S transgenic mice exhibit a pronounced increase in the length of bones, such as femur, tibia, and vertebrae. The effect of ADAM12-S on longitudinal bone growth involves the modulation of chondrocyte proliferation and maturation, likely through proteolytic activities and altered cell-extracellular matrix interactions in the growth plate. INTRODUCTION: The disintegrin and metalloprotease ADAM12...

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Identifiers

PMID: 16869727
DOI: 10.1359/jbmr.060502

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