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Article

A critical role for interleukin-6 family-mediated Stat3 activation in osteoblast differentiation and bone formation.

Bone - 1 Sept 2006

Itoh Shousaku, Udagawa Nobuyuki, Takahashi Naoyuki, Yoshitake Fumio, Narita Hiroko, Ebisu Shigeyuki, Ishihara Katsuhiko

Abstract excerpt

Signal transduction and activator of transcription (Stat) 3 is a transcription factor that is activated by a variety of cytokines and growth factors, including IL-6 family cytokines. These cytokines regulate bone homeostasis and have been reported to regulate the differentiation of osteoblasts and osteoclasts through Stat3 activation in vitro, but the in vivo physiological role of Stat3 in bone homeostasis is...

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Identifiers

PMID: 16679075
DOI: 10.1016/j.bone.2006.02.074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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