Article
Evolution of HIV resistance mutations in patients maintained on a stable treatment regimen after virologic failure.
Journal of acquired immune deficiency syndromes (1999) - 15 Dec 2006
Goetz Matthew Bidwell, Ferguson Monique R, Han Xueliang, McMillan Greg, St Clair Marty, Pappa Keith A, McClernon Daniel R, O'Brien William A
Abstract excerpt
OBJECTIVE: We compared the rate of emergence of thymidine analogue mutations (TAMs) and major protease inhibitor mutations in adherent patients who remained on stable treatment with a thymidine analogue and/or protease inhibitor after the onset of virologic failure. DESIGN: Follow-up genotypic resistance testing was done using archived plasma obtained from patients having 0 or 1 TAM and/or 0 or 1 major protease...
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