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Evolution of Integrase Resistance During Failure of Integrase Inhibitor-Based Antiretroviral Therapy

18 Mar 2010

Abstract excerpt

BACKGROUND: Although integrase inhibitors are highly effective in the management of drug-resistant HIV, some patients fail to achieve durable viral suppression. The long-term consequences of integrase inhibitor failure have not been well defined. METHODS: We identified 29 individuals who exhibited evidence of incomplete viral suppression on a regimen containing an integrase inhibitor (23 raltegravir, 6...

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PMID: 20300008
DOI: 10.1097/qai.0b013e3181c42ea4

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