Article
Emerging mutations at virological failure of HAART combinations containing tenofovir and lamivudine or emtricitabine.
AIDS (London, England) - 24 Apr 2010
Maserati Renato, De Silvestri Annalisa, Uglietti Alessia, Colao Grazia, Di Biagio Antonio, Bruzzone Bianca, Di Pietro Massimo, Re Maria Carla, Tinelli Carmine, Zazzi Maurizio
Abstract excerpt
OBJECTIVE: To compare the emergence of drug-resistant HIV variants at failure of lamivudine (3TC)/tenofovir (TDF)-containing or emtricitabine (FTC)/TDF-containing HAART as a consequence of the different 3TC and FTC intracellular half-lives. DESIGN: Retrospective evaluation of 859 patients selecte...
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