Article
Kinetics of HIV-1 RNA and resistance-associated mutations after cessation of antiretroviral combination therapy.
AIDS (London, England) - 27 Jul 2001
Birk M, Svedhem V, Sönnerborg A
Abstract excerpt
OBJECTIVE: To study the kinetics of HIV-1 RNA and drug-induced mutations after cessation of antiretroviral therapy (ART). DESIGN AND METHODS: Successive plasma samples from 26 patients were tested for HIV-1 RNA by PCR and for mutations associated with drug resistance by sequencing of the pol gene. RESULTS: After cessation of ART the phase of undetectable virus (< 50 copies/ml), ranging from 6 to more than 29...
Topics
- Adult
- Anti-HIV Agents
- Drug Resistance, Microbial
- Drug Therapy, Combination
- Female
- Genes, pol
- HIV Infections
- HIV-1
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction
- RNA, Viral
- Sequence Analysis, RNA
- Viral Load