Article
Evolution of HIV resistance during treatment interruption in experienced patients and after restarting a new therapy.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2005
Balduin Melanie, Sierra Saleta, Däumer Martin P, Rockstroh Jürgen K, Oette Mark, Fätkenheuer Gerd, Kupfer Bernd, Beerenwinkel Niko, Hoffmann Daniel, Selbig Joachim, Pfister Herbert J, Kaiser Rolf
Abstract excerpt
BACKGROUND: To analyse the evolution of resistance patterns in patients undergoing treatment interruption (TI) and re-initiating highly active anti-retroviral therapy (HAART). METHODS: HIV-RT and -PR gene-sequences were analysed in 14 patients (>5 failing prior drugs) before and during TI and under a new HAART. Genotypes were interpreted using two bioinformatics systems. Additionally, virus load (VL) and...
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