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Article

Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2006

Cyr Michel, Sotnikova Tatyana D, Gainetdinov Raul R, Caron Marc G

Abstract excerpt

An expansion in the CAG repeat of the IT15 (huntingtin) gene underlies the development of Huntington's disease (HD), but the basis for the specific vulnerability of dopamine-receptive striatal neurons remains unclear. To examine the potential role of the dopamine system in the emergence of pathological conditions in HD, we generated a double mutant mouse strain with both enhanced dopamine transmission and...

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Identifiers

PMID: 17065224
DOI: 10.1096/fj.06-6533fje

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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