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Article

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jun 1999

Reddy P H, Charles V, Williams M, Miller G, Whetsell W O, Tagle D A

Abstract excerpt

Huntington's disease (HD) is a progressive neurodegenerative disorder characterized clinically by motor and psychiatric disturbances and pathologically by neuronal loss and gliosis (reactive astrocytosis) particularly in the striatum and cerebral cortex. We have recently created HD full-length cDNA transgenic mouse models that may serve as a paradigm for HD. A more detailed characterization of these models is...

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Identifiers

PMID: 10434303
DOI: 10.1098/rstb.1999.0456
PMCID: PMC1692609

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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