Mouse models of Huntington's disease.

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder. In 1993 the mutation that causes HD was identified as an unstable expansion of CAG repeats in the IT15 gene. Since then one of the most important advances in HD research has been the generation of various mouse models that enable the exploration of early pathological, molecular and cellular abnormalities produced by the mutation. In...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Creatine
• Share to Enzyme Inhibitors
• Share to Huntingtin Protein