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AAV9-Mediated Intrastriatal Delivery of Mutant HTT With 82 CAG Repeats Induces Huntington's Disease-Like Pathology and Behavioral Deficits in Mice.

Clinical genetics - 1 Mar 2026

Huang Lin, Tang Yazhou, Wang Yuan, Tan Yali, Lei Wei, Deng Xinyu, Luo Yongjie

Abstract excerpt

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by CAG repeat expansion in the HTT gene. Existing toxin-induced and genetic models provide important insights, but none fully replicate the progressive pathology of HD. An AAV9-mediated striatal mouse model expressing mutant HTT with 82 CAG repeats was established to reproduce hallmark neuropathological changes and behavioral...

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Identifiers

PMID: 41139934
DOI: 10.1111/cge.70076

Genes

HTT
GFAP

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