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Article

Longitudinal Evaluation of the<i>Hdh</i><sup>(CAG)150</sup>Knock-In Murine Model of Huntington's Disease

22 Aug 2007

Abstract excerpt

Several murine genetic models of Huntington's disease (HD) have been developed. Murine genetic models are crucial for identifying mechanisms of neurodegeneration in HD and for preclinical evaluation of possible therapies for HD. Longitudinal analysis of mutant phenotypes is necessary to validate models and to identify appropriate periods for analysis of early events in the pathogenesis of neurodegeneration. Here...

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Identifiers

PMID: 17715336
DOI: 10.1523/jneurosci.1830-07.2007

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