Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neurological abnormalities in a knock-in mouse model of Huntington's disease.

Human molecular genetics - 15 Jan 2001

Lin C H, Tallaksen-Greene S, Chien W M, Cearley J A, Jackson W S, Crouse A B, Ren S, Li X J, Albin R L, Detloff P J

Abstract excerpt

Mice representing precise genetic replicas of Huntington's disease (HD) were made using gene targeting to replace the short CAG repeat of the mouse Huntington's disease gene homolog (HDH:) with CAG repeats within the length range found to cause HD in humans. Mice with alleles of approximately 150 units in length exhibit late-onset behavioral and neuroanatomic abnormalities consistent with HD. These symptoms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glial Fibrillary Acidic Protein
Share to Gliosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Growth Disorders

Share to Huntingtin Protein

Share to Huntington Disease

Share to Inclusion Bodies

Share to Mice, Neurologic Mutants

Share to Trinucleotide Repeat Expansion

Source

Identifiers

PMID: 11152661
DOI: 10.1093/hmg/10.2.137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neurological abnormalities in a knock-in mouse model of Huntington's disease.PMID 11152661Read ↗

Mouse Models of Huntington's Disease.Semantic proximity Read ↗

Early white matter abnormalities, progressive brain pathology and motor deficits in a novel knock-in mouse model of Huntington's disease.Semantic proximity Read ↗

Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.Semantic proximity Read ↗

The use of transgenic and knock-in mice to study Huntington's disease.Semantic proximity Read ↗

Longitudinal Evaluation of the<i>Hdh</i><sup>(CAG)150</sup>Knock-In Murine Model of Huntington's DiseaseSemantic proximity Read ↗

Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease miceSemantic proximity Read ↗

Transgenic mice expressing mutated full-length HD cDNA: a paradigm for locomotor changes and selective neuronal loss in Huntington's disease.Semantic proximity Read ↗

Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.Semantic proximity Read ↗

Overview of Huntington's Disease Models: Neuropathological, Molecular, and Behavioral Differences.Semantic proximity Read ↗

Striatal pathology in Spinocerebellar Ataxia Type 1 mice: A comparative study with Huntington’s diseaseSemantic proximity Read ↗

Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.Semantic proximity Read ↗

Huntingtin Aggregate-Associated Axonal Degeneration is an Early Pathological Event in Huntington's Disease MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.