Article
Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2002
Menalled Liliana B, Sison Jessica D, Wu Ying, Olivieri Melisa, Li Xiao-Jiang, Li He, Zeitlin Scott, Chesselet Marie-Françoise
Abstract excerpt
Huntington's disease (HD) is characterized by a progressive loss of neurons in the striatum and cerebral cortex and is caused by a CAG repeat expansion in the gene encoding huntingtin. Mice with the mutation inserted into their own huntingtin gene (knock-in mice) are, genetically, the best models of the human disease. Here we show for the first time that knock-in mice with 94 CAG repeats develop a robust and...
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