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Article

PP2A and E3 ubiquitin ligase deficiencies: Seminal biological drivers in endometrial cancer.

Gynecologic oncology - 1 Jul 2021

Gonzalez-Bosquet Jesus, Bakkum-Gamez Jamie N, Weaver Amy L, McGree Michaela E, Dowdy Sean C, Famuyide Abimbola O, Kipp Benjamin R, Halling Kevin C, Couch Fergus J, Podratz Karl C

Abstract excerpt

OBJECTIVE: PI3K-AKT pathway mutations initiate a kinase cascade that characterizes endometrial cancer (EC). As kinases seldom cause oncogenic transformation without dysregulation of antagonistic phosphatases, pivotal interactions governing this pathway were explored and correlated with clinical outcomes. METHODS: After exclusion of patients with POLE mutations from The Cancer Genome Atlas EC cohort with...

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PMID: 33867147
DOI: 10.1016/j.ygyno.2021.04.008

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